Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 3/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907463 | 0.83 | KDM4E (0.53) | GABRA1GABRB2ALDH1A1KMT2AKDM4E | |
| SCHEMBL6180298 | 0.81 | KMT2A (0.41) | GABRA1GABRB2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL7324343 | 0.76 | CA12 (0.42) | ALDH1A1GAAL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL7323725 | 0.74 | TSHR (0.41) | GABRA1GABRB2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL15676611 | 0.74 | RIPK1 (0.43) | ALDH1A1L3MBTL1KDM4EHSD17B10CXCL8 | |
| SCHEMBL7737265 | 0.73 | HTR2A (0.43) | GABRA1GABRB2L3MBTL1CXCL8HTR1A | |
| SCHEMBL8340504 | 0.71 | KDM4E (0.45) | GABRA1GABRB2L3MBTL1KDM4EHTR1A | |
| SCHEMBL1805352 | 0.70 | PPARG (0.43) | ALDH1A1KMT2AL3MBTL1PPARAPPARG | |
| SCHEMBL7329544 | 0.69 | HSD17B10 (0.51) | ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL10931666 | 0.68 | GABRA1 (0.39) | GABRA1GABRB2ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |