Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TLR3 | O15455 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.30 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321412 | 0.89 | ABCC9 (0.39) | ABCC9AKR1B1HIF1ATLR3LMNA | |
| SCHEMBL7324168 | 0.82 | ABCC9 (0.38) | ABCC9HIF1ATDP1KCNE1KCNQ1 | |
| SCHEMBL8084467 | 0.81 | ABCC9 (0.38) | ABCC9AKR1B1HIF1ATLR3LMNA | |
| SCHEMBL8085013 | 0.81 | ABCC9 (0.41) | ABCC9TLR3LMNAMAPTHTT | |
| SCHEMBL7331791 | 0.81 | ABCC9 (0.40) | ABCC9HIF1ATLR3LMNAMAPT | |
| SCHEMBL7331033 | 0.80 | ABCC9 (0.35) | ABCC9AKR1B1HIF1ATLR3LMNA | |
| SCHEMBL7326918 | 0.80 | AKR1B1 (0.35) | ABCC9AKR1B1TLR3LMNAMAPT | |
| SCHEMBL7333125 | 0.80 | ABCC9 (0.56) | ABCC9KCNE1KCNQ1 | |
| SCHEMBL7326453 | 0.76 | ABCC9 (0.38) | ABCC9AKR1B1HIF1ATLR3LMNA | |
| SCHEMBL7331872 | 0.74 | ABCC9 (0.33) | ABCC9TLR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0363883-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1990-04-18 | — | — | EP | disclosed |