Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TLR3 | O15455 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085199 | 0.82 | ABCC9 (0.42) | ABCC9NPC1RAB9A | |
| SCHEMBL7323754 | 0.81 | ABCC9 (0.39) | ABCC9ALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL7321412 | 0.81 | ABCC9 (0.39) | ABCC9ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL7326453 | 0.80 | ABCC9 (0.38) | ABCC9KMT2AMEN1HTTMAPT | |
| SCHEMBL8184473 | 0.80 | ALDH1A1 (0.37) | ABCC9ALDH1A1KMT2AMEN1PDE7A | |
| SCHEMBL8088486 | 0.80 | ABCC9 (0.42) | ABCC9PKMHTTMAPTKDM4E | |
| SCHEMBL7274240 | 0.80 | ABCC9 (0.62) | ABCC9KDM4E | |
| SCHEMBL8084467 | 0.79 | ABCC9 (0.38) | ABCC9HTTMAPTSMN1; SMN2LMNA | |
| SCHEMBL7331791 | 0.78 | ABCC9 (0.40) | ABCC9ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL9589058 | 0.78 | ABCC9 (0.48) | ABCC9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |