Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324782 | 0.85 | QDPR (0.46) | SLC6A3SLC6A2ALOX5SLC6A4PARP1 | |
| Bromide SCHEMBL7300676 | 0.82 | QDPR (0.46) | SLC6A3SLC6A2ALOX5SLC6A4PARP1 | |
| Bromide SCHEMBL7300656 | 0.82 | QDPR (0.46) | SLC6A3SLC6A2ALOX5SLC6A4PARP1 | |
| Bromide SCHEMBL7300664 | 0.82 | QDPR (0.46) | SLC6A3SLC6A2ALOX5SLC6A4PARP1 | |
| SCHEMBL7333836 | 0.81 | KDM1A (0.47) | ALOX5PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL7297389 | 0.81 | PARP1 (0.50) | ALOX5PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL7293987 | 0.81 | PARP1 (0.50) | ALOX5PARP1HTR2AHTR2CHTR2B | |
| SCHEMBL7293999 | 0.81 | PARP1 (0.50) | ALOX5PARP1HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9427149 | 0.80 | PARP1 (0.49) | ALOX5PARP1HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL7294464 | 0.80 | PARP1 (0.49) | ALOX5PARP1QDPRMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444083-A | DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0381235-B1 | PYRROLIDINE COMPOUND AND PHARMACEUTICAL USE | Eisai Co., Ltd. (JP) | 1993-07-28 | — | — | EP | disclosed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |