Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 18/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304157 | 0.87 | DHPS (0.56) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL7330437 | 0.83 | DHPS (0.59) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL31037825 | 0.79 | DHPS (0.62) | DHPSALDH1A1L3MBTL1 | |
| SCHEMBL31037801 | 0.79 | DHPS (0.82) | DHPSMAPK1L3MBTL1 | |
| SCHEMBL7204802 | 0.79 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL5632471 | 0.79 | DHPS (0.57) | DHPSALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL8323583 | 0.78 | ALDH1A1 (0.38) | DHPSALDH1A1L3MBTL1CA12CA1 | |
| SCHEMBL31037848 | 0.77 | DHPS (0.70) | DHPSALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL31037823 | 0.77 | DHPS (0.60) | DHPSALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL31037842 | 0.77 | DHPS (0.70) | DHPSALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |