Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331083 | 0.96 | NR4A2 (0.54) | NR4A2HTR4CACNA1IKCNH2 | |
| SCHEMBL7332743 | 0.85 | HTR4 (0.39) | NR4A2HTR4KCNH2 | |
| SCHEMBL7332753 | 0.84 | HTR4 (0.53) | HTR4 | |
| SCHEMBL7324669 | 0.81 | HTR4 (0.38) | NR4A2HTR4 | |
| SCHEMBL7328044 | 0.80 | HTR4 (0.56) | HTR4 | |
| SCHEMBL7325370 | 0.79 | NR4A2 (0.54) | NR4A2HTR4 | |
| SCHEMBL7353765 | 0.79 | NR4A2 (0.51) | NR4A2HTR4CACNA1IKCNH2 | |
| SCHEMBL7328039 | 0.76 | HTR4 (0.41) | NR4A2HTR4KCNH2 | |
| SCHEMBL5364372 | 0.73 | HTR4 (0.58) | HTR4 | |
| SCHEMBL6175694 | 0.72 | NR4A2 (0.49) | NR4A2HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664806-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008995-A1 | HETEROCYCLIC CONDENSED BENZOIC ACID DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | disclosed |