Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.50 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331083 | 0.82 | NR4A2 (0.54) | NR4A2HTR4CACNA1IKCNH2 | |
| SCHEMBL7324673 | 0.79 | NR4A2 (0.51) | NR4A2HTR4CACNA1IKCNH2 | |
| SCHEMBL6176072 | 0.77 | KCNH2 (0.52) | NR4A2HTR4KCNH2 | |
| SCHEMBL6175694 | 0.76 | NR4A2 (0.49) | NR4A2HTR4 | |
| SCHEMBL5364372 | 0.75 | HTR4 (0.58) | HTR4 | |
| SCHEMBL6179599 | 0.75 | NR4A2 (0.48) | NR4A2HTR4 | |
| Hydrochloric Acid SCHEMBL7414089 | 0.74 | HTR4 (0.58) | HTR4 | |
| SCHEMBL7348053 | 0.74 | HTR3A (0.51) | HTR4 | |
| SCHEMBL7325370 | 0.72 | NR4A2 (0.54) | NR4A2HTR4 | |
| SCHEMBL6333842 | 0.72 | HTR4 (0.58) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664794-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | claimed |
| WO-1994008965-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | claimed |
| US-5726187-A | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-03-10 | — | — | US | disclosed |
| EP-0664794-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008965-A1 | N-ALKYLPIPERIDINYL-4-METHYL CARBOXYLIC ESTERS/AMIDES OF CONDENSED RING SYSTEMS AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-28 | — | — | WO | disclosed |