SCHEMBL7324705

SCHEMBL7324705

CC(NS(=O)(=O)N1CCN(c2ccc(Cl)cc2)CC1)C(=O)NO

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
MMP14 P50281 2/20 0.47
ADAMTS5 Q9UNA0 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.46
HDAC1 Q13547 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
MAPT P10636 4/20 0.45
TP53 P04637 1/20 0.45
DRD2 P14416 1/20 0.45
DRD4 P21917 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4674851 0.88 MMP1 (0.57) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4674856 0.88 MMP1 (0.57) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4673962 0.87 MMP14 (0.52) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4671242 0.87 MMP14 (0.52) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4671248 0.87 MMP14 (0.52) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4673723 0.85 MEN1 (0.52) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4673727 0.85 MEN1 (0.52) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4671091 0.84 SMN1; SMN2 (0.46) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4671098 0.84 SMN1; SMN2 (0.46) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2
SCHEMBL4677143 0.82 SMN1; SMN2 (0.45) MEN1KMT2AMMP14ADAMTS5SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376506-B1 REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS SYNTEX (U.S.A.) LLC 2002-04-23 US disclosed
US-6130220-A ENZYME INHIBITORS SYNTEX (USA) INC. (US) 2000-10-10 US disclosed
US-5998412-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS SYNTEX (U.S.A.) INC. (US) 1999-12-07 US disclosed