Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28068136 | 0.84 | MEN1 (0.40) | SMN1; SMN2LMNAL3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL4595422 | 0.74 | FFAR1 (0.42) | — | |
| SCHEMBL4068261 | 0.72 | SLC6A2 (0.41) | SMN1; SMN2L3MBTL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8948307 | 0.71 | KDM4E (0.44) | KCNA5KCNH2SMN1; SMN2TBXAS1ALDH1A1 | |
| SCHEMBL11006868 | 0.70 | TBXAS1 (0.45) | KCNA5SMN1; SMN2TBXAS1ALDH1A1LMNA | |
| SCHEMBL10613169 | 0.69 | SMN1; SMN2 (0.49) | KCNA5SMN1; SMN2TBXAS1ALDH1A1LMNA | |
| SCHEMBL25152962 | 0.69 | ITGB3 (0.47) | SMN1; SMN2TBXAS1LMNAL3MBTL1CFTR | |
| SCHEMBL11861003 | 0.69 | KCNA5 (0.51) | KCNA5KCNH2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL25152516 | 0.69 | ITGB3 (0.47) | SMN1; SMN2TBXAS1LMNAL3MBTL1CFTR | |
| SCHEMBL11870969 | 0.68 | KCNA5 (0.45) | KCNA5KCNH2SMN1; SMN2LMNACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |