Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329565 | 0.92 | DRD2 (0.77) | DRD2HTR2AGRM2KDM4EALDH1A1 | |
| SCHEMBL7328659 | 0.92 | DRD2 (0.77) | DRD2HTR2AGRM2KDM4EALDH1A1 | |
| SCHEMBL7331312 | 0.88 | DRD2 (0.71) | DRD2HTR2AGRM2KDM4EALDH1A1 | |
| SCHEMBL7327581 | 0.88 | DRD2 (0.58) | DRD2HTR2AGRM2MAPTACHE | |
| SCHEMBL7326283 | 0.87 | DRD2 (0.84) | DRD2HTR2AKDM4EALDH1A1LMNA | |
| SCHEMBL7325078 | 0.81 | HTR2A (0.80) | DRD2HTR2AKDM4ELMNAMAPT | |
| SCHEMBL7328292 | 0.80 | HTR2A (0.79) | DRD2HTR2ASIGMAR1HTR1ACYP1A2 | |
| Blonanserin SCHEMBL29379647 | 0.78 | DRD2 (1.00) | DRD2HTR2AKDM4EALDH1A1LMNA | |
| Blonanserin SCHEMBL119669 | 0.78 | DRD2 (1.00) | DRD2HTR2AKDM4EALDH1A1LMNA | |
| SCHEMBL7334897 | 0.78 | DRD2 (1.00) | DRD2HTR2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-B1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5021421-A | Psychotropic agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0385237-A2 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |