Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.79 |
| ▸ | DRD2 | P14416 | 9/20 | 0.79 |
| ▸ | HTR1A | P08908 | 10/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325078 | 0.97 | HTR2A (0.80) | HTR2ADRD2HTR1ADRD4DRD3 | |
| SCHEMBL7326283 | 0.93 | DRD2 (0.84) | HTR2ADRD2HTR1AHTR3ACYP1A2 | |
| SCHEMBL7327857 | 0.90 | HTR2A (0.75) | HTR2ADRD2HTR1ADRD4DRD3 | |
| Blonanserin SCHEMBL119669 | 0.88 | DRD2 (1.00) | HTR2ADRD2CYP1A2CYP3A4 | |
| SCHEMBL7334897 | 0.88 | DRD2 (1.00) | HTR2ADRD2CYP1A2CYP3A4 | |
| SCHEMBL7326794 | 0.87 | HTR2A (0.78) | HTR2ADRD2HTR3AHTR2CCYP1A2 | |
| Blonanserin SCHEMBL28331931 | 0.87 | DRD2 (0.98) | HTR2ADRD2CYP1A2CYP3A4 | |
| Blonanserin SCHEMBL28204389 | 0.87 | DRD2 (0.98) | HTR2ADRD2CYP1A2CYP3A4 | |
| SCHEMBL7333664 | 0.86 | DRD2 (0.76) | HTR2ADRD2DRD3SLC6A4DRD1 | |
| SCHEMBL7333157 | 0.85 | DRD2 (0.93) | HTR2ADRD2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385237-B1 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1994-06-29 | — | — | EP | disclosed |
| US-5021421-A | Psychotropic agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0385237-A2 | 2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-09-05 | — | — | EP | disclosed |