Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313420 | 0.87 | ROCK2 (0.39) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL4782353 | 0.79 | CHRM1 (0.52) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL4730348 | 0.77 | CHRM1 (0.53) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7320742 | 0.76 | CHRM1 (0.42) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7327666 | 0.76 | CHRM1 (0.46) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL4782719 | 0.75 | POLB (0.51) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7326984 | 0.73 | CHRM1 (0.46) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7317880 | 0.73 | CHRM1 (0.54) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7318271 | 0.71 | CHRM1 (0.55) | CHRM1ROCK2ROCK1PRKXPRKCE | |
| SCHEMBL7323647 | 0.71 | ROCK2 (0.39) | CHRM1ROCK2ROCK1PRKXPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287696-B1 | ISOQUINOLINE DERIVATIVES | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-01-02 | — | — | EP | disclosed |
| EP-0287696-A1 | Isoquinoline derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1988-10-26 | — | — | EP | disclosed |