Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | SOS1 | Q07889 | 6/20 | 0.63 |
| ▸ | KRAS | P01116 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | BCHE | P06276 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314479 | 0.92 | SOS1 (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11311300 | 0.91 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11303310 | 0.90 | ADRA2A (0.85) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11307554 | 0.90 | MEN1 (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11309889 | 0.89 | DRD4 (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11545694 | 0.89 | ADRA2A (0.83) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11304016 | 0.88 | SIGMAR1 (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11309919 | 0.86 | SIGMAR1 (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11303296 | 0.85 | SOS1 (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11311140 | 0.82 | SOS1 (0.73) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216247-A2 | Use of alpha 2 adrenergic receptor antagonists for the production of pharmaceutical compositions for treating colonic spasm, irritable bowel syndrome and constipation and process for preparing such pharmaceutical compositions | MERCK & CO. INC. (US) | 1987-04-01 | — | — | EP | claimed |
| EP-0002886-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | JOHN WYETH & BROTHER LIMITED (GB) | 1981-10-14 | — | — | EP | claimed |
| US-4209521-A | Anti-depressant indole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1980-06-24 | — | — | US | claimed |
| EP-0002886-A2 | Indole derivatives, their preparation and use in pharmaceutical compositions | JOHN WYETH & BROTHER LIMITED (GB) | 1979-07-11 | — | — | EP | claimed |
| US-20020173511-A1 | Serotonergic compositions and methods for treatment of mild cognitive impairment | WURTMAN RICHARD J (US) | 2002-11-21 | — | — | US | disclosed |
| WO-2002038142-A2 | SEROTONERGIC COMPOSITIONS AND METHODS FOR TREATMENT OF MILD COGNITIVE IMPAIRMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-05-16 | — | — | WO | disclosed |
| EP-0386117-B1 | TREATING PREMENSTRUAL OR LATE LUTEAL PHASE SYNDROME | MASSACHUSETTS INST TECHNOLOGY (US) | 1999-01-07 | — | — | EP | disclosed |
| US-5223540-A | Fluvoxamine | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1993-06-29 | — | — | US | disclosed |
| US-5179126-A | Compositions for treating tobacco withdrawl symtoms and methods for their use | MASSACHUSETTES INSTITUTE OF TECHNOLOGY (US) | 1993-01-12 | — | — | US | disclosed |
| WO-1992002215-A1 | METHOD FOR TREATING THE PREMENSTRUAL OR LATE LUTEAL PHASE SYNDROME | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-02-20 | — | — | WO | disclosed |
| US-4999382-A | Compositions for treating tobacco withdrawal symptoms and methods for their use | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1991-03-12 | — | — | US | disclosed |
| US-4971998-A | MENSTRUATION, FENFLURAMINE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0386117-A1 | TREATING PREMENSTRUAL OR LATE LUTEAL PHASE SYNDROME | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1990-09-12 | — | — | EP | disclosed |
| WO-1989003692-A1 | TREATING PREMENSTRUAL OR LATE LUTEAL PHASE SYNDROME | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1989-05-05 | — | — | WO | disclosed |
| US-4673680-A | 1,3,4,6,7,12B-HEXAHYDRO-2H-BENZO(B)(FURO OR THIENO)(2,3-A) QUINOLIZIN-2-YL-AMINE DERIVATIVES | MERCK & CO., INC., A CORP. OF NJ | 1987-06-16 | — | — | US | disclosed |
| EP-0216247-A2 | Use of alpha 2 adrenergic receptor antagonists for the production of pharmaceutical compositions for treating colonic spasm, irritable bowel syndrome and constipation and process for preparing such pharmaceutical compositions | MERCK & CO. INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0002886-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | JOHN WYETH & BROTHER LIMITED (GB) | 1981-10-14 | — | — | EP | disclosed |
| US-4209521-A | Anti-depressant indole derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1980-06-24 | — | — | US | disclosed |
| EP-0002886-A2 | Indole derivatives, their preparation and use in pharmaceutical compositions | JOHN WYETH & BROTHER LIMITED (GB) | 1979-07-11 | — | — | EP | disclosed |