SCHEMBL7325429

SCHEMBL7325429

COC(=O)[C@H](Cc1ccc(NS(=O)(=O)CCl)cc1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 3/20 0.56
MAPK1 P28482 2/20 0.52
TSHR P16473 1/20 0.52
ITGB1 P05556 5/20 0.52
ITGA5 P08648 3/20 0.52
L3MBTL1 Q9Y468 2/20 0.49
ITGAV P06756 1/20 0.48
RAB9A P51151 1/20 0.47
PLAU P00749 1/20 0.47
HPN P05981 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
FKBP1A P62942 1/20 0.47
MAPT P10636 1/20 0.46
HCRTR1 O43613 2/20 0.46
HCRTR2 O43614 2/20 0.46
CYP3A4 P08684 1/20 0.46
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175597 0.91 ITGA4 (0.57) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL7187629 0.91 ITGB1 (0.62) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL5690625 0.90 MAPK1 (0.66) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL6712426 0.89 ITGA4 (0.59) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL7316171 0.88 ITGA4 (0.54) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL7320858 0.88 ITGA4 (0.54) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL6710616 0.88 MAPK1 (0.58) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL3849601 0.88 ITGA4 (0.60) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL5690332 0.87 ITGA4 (0.59) ITGA4MAPK1TSHRITGB1ITGA5
SCHEMBL6709486 0.87 ITGA4 (0.59) ITGA4MAPK1TSHRITGB1ITGA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO claimed
US-6492421-B1 BINDING VERY LATE ANTIGEN-4; INFLAMMATORY DISEASES SUCH AS ASTHMA, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AIDS, DEMENTIA, DIABETES, INFLAMMATORY BOWEL DISEASE, RHEUMATOID ARTHRITIS, TISSUE TRANSPLANTATION, TUMOR METASTASIS, MYOCARDIAL ISCHEMIA ATHENA NEUROSCIENCES, INC. 2002-12-10 US disclosed
EP-1001972-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006431-A1 SUBSTITUTED PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed