Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 11/20 | 0.62 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.62 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.61 |
| ▸ | ITGAV | P06756 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | HPN | P05981 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325429 | 0.91 | ITGA4 (0.56) | ITGB1ITGA5ITGA4ITGAVMAPK1 | |
| SCHEMBL6709406 | 0.91 | ITGB1 (0.64) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL5690742 | 0.89 | ITGB1 (0.71) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL6712427 | 0.88 | ITGA4 (0.65) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL7327937 | 0.88 | ITGB1 (0.61) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL7322859 | 0.88 | ITGB1 (0.61) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL6709558 | 0.88 | ITGB1 (0.69) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL6708116 | 0.87 | ITGB1 (0.60) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL6714530 | 0.87 | ITGA4 (0.66) | ITGB1ITGA5ITGA4ITGAVALDH1A1 | |
| SCHEMBL7069740 | 0.87 | ALDH1A1 (0.70) | ITGB1ITGA5ITGA4ITGAVALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583139-B1 | Treatment of inflammatory diseases; inflammatory brain diseases such as multiple sclerosis; N-(Toluene-4-sulfonyl)-L-prolyl-4-(alpha -methylbenzyloxy)-L-phenylalanine; Very Late Antigen 4 | BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) | 2003-06-24 | — | — | US | claimed |
| US-6583139-B1 | Treatment of inflammatory diseases; inflammatory brain diseases such as multiple sclerosis; N-(Toluene-4-sulfonyl)-L-prolyl-4-(alpha -methylbenzyloxy)-L-phenylalanine; Very Late Antigen 4 | BIOGEN IDEC INTERNATIONAL HOLDING LTD. (BM) | 2003-06-24 | — | — | US | disclosed |