Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325502 | 0.87 | ADRA1A (0.48) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9049059 | 0.83 | HTR3A (0.39) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL3176458 | 0.79 | ADRA1A (0.42) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL3184840 | 0.77 | ADRA1A (0.41) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL13531413 | 0.77 | HTR3A (0.42) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL6850928 | 0.75 | HTR3A (0.38) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL6847058 | 0.74 | ADRA1A (0.42) | ADRA1AOPRK1ADRA1D | |
| Sulfuric Acid SCHEMBL7331483 | 0.74 | ADRA1A (0.38) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| SCHEMBL1417641 | 0.74 | HTR3A (0.40) | ADRA1AHTR3AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL3453049 | 0.73 | ADRA1A (0.41) | ADRA1AOPRK1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1027536-C | Process for producing 4,5,6,7-tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1995-02-01 | — | — | CN | disclosed |
| EP-0376624-B1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-4977175-A | GASTROINTESTINAL DISORDERS, ANTIEMETICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| CN-1043706-A | 4,5,6,7-tetrahydrobenzene benzimidazole derivative preparation method | YAMANOUCHI PHARMA CO LTD (JP) | 1990-07-11 | — | — | CN | disclosed |
| EP-0376624-A1 | 4,5,6,7-Tetrahydrobenzimidazole derivatives and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-07-04 | — | — | EP | disclosed |