Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.86 |
| ▸ | ADAM17 | P78536 | 19/20 | 0.86 |
| ▸ | MMP13 | P45452 | 19/20 | 0.86 |
| ▸ | MMP9 | P14780 | 4/20 | 0.86 |
| ▸ | MMP3 | P08254 | 3/20 | 0.86 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.86 |
| ▸ | ADAM9 | Q13443 | 2/20 | 0.86 |
| ▸ | MMP2 | P08253 | 2/20 | 0.84 |
| ▸ | MMP7 | P09237 | 1/20 | 0.71 |
| ▸ | MMP8 | P22894 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941871 | 1.00 | MMP1 (0.86) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL7325140 | 0.93 | MMP1 (0.86) | MMP1ADAM17MMP13MMP9MMP3 | |
| Apratastat SCHEMBL2834310 | 0.93 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9MMP3 | |
| Apratastat SCHEMBL3946334 | 0.93 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9MMP3 | |
| Apratastat SCHEMBL7430863 | 0.92 | MMP1 (0.98) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL3948013 | 0.92 | MMP1 (0.85) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL6498529 | 0.92 | MMP1 (1.00) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL2358255 | 0.92 | ADAM17 (1.00) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL3942486 | 0.92 | ADAM17 (1.00) | MMP1ADAM17MMP13MMP9MMP3 | |
| SCHEMBL8051411 | 0.92 | MMP1 (0.86) | MMP1ADAM17MMP13MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387901-B1 | ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | PFIZER INC | 2002-05-14 | — | — | US | disclosed |