Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 9/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 3/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354943 | 0.78 | HCAR1 (0.40) | HCAR1CA12CA9F9 | |
| SCHEMBL20660673 | 0.76 | CA12 (0.44) | HCAR1CA12CA9ARTHRB | |
| SCHEMBL7324054 | 0.76 | HCAR1 (0.38) | HCAR1CA12CA9THRBHPGD | |
| SCHEMBL15828550 | 0.74 | HCAR1 (0.37) | HCAR1CA12CA9ARTHRB | |
| SCHEMBL31118648 | 0.73 | F11 (0.46) | HCAR1CA12CA9ARTHRB | |
| SCHEMBL19751539 | 0.73 | CA12 (0.46) | HCAR1CA12CA9ARHPGD | |
| SCHEMBL5134130 | 0.67 | CA12 (0.59) | HCAR1CA12CA9HPGDSMN1; SMN2 | |
| SCHEMBL7311415 | 0.64 | PDE3B (0.45) | HCAR1 | |
| SCHEMBL7349312 | 0.63 | PDE3B (0.50) | — | |
| SCHEMBL7315492 | 0.63 | NOTUM (0.40) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |