SCHEMBL7325928

SCHEMBL7325928

C[C@@H](OC1(c2cccs2)c2ccccc2-c2ccccc21)[C@H](N)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 4/20 0.41
SLC1A2 P43004 4/20 0.41
SLC1A1 P43005 4/20 0.41
CYP1A2 P05177 2/20 0.36
CYP2C19 P33261 2/20 0.36
MEN1 O00255 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
KMT2A Q03164 1/20 0.36
SLC6A3 Q01959 1/20 0.35
KIF11 P52732 4/20 0.34
ALDH1A1 P00352 2/20 0.34
TP53 P04637 1/20 0.34
HTT P42858 1/20 0.34
PDK2 Q15119 1/20 0.34
ALOX5 P09917 1/20 0.33
THRB P10828 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HCAR2 Q8TDS4 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7325924 1.00 SLC1A3 (0.41) SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19
SCHEMBL7316697 0.91 KIF11 (0.36) SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19
SCHEMBL7316689 0.91 KIF11 (0.36) SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19
SCHEMBL7313476 0.90 PDK2 (0.36) SLC1A3SLC1A2SLC1A1MEN1KMT2A
SCHEMBL7313467 0.90 PDK2 (0.36) SLC1A3SLC1A2SLC1A1MEN1KMT2A
SCHEMBL7312511 0.89 PDK2 (0.39) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL7315669 0.89 PDK2 (0.39) SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19
SCHEMBL7315663 0.89 PDK2 (0.39) SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19
SCHEMBL7312498 0.89 PDK2 (0.39) SLC1A3SLC1A2SLC1A1CYP1A2MEN1
SCHEMBL7322653 0.89 PDK2 (0.34) SLC1A3SLC1A2SLC1A1KIF11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999041227-A1 TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-08-19 WO claimed
US-6162824-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS ALLELIX NEUROSCIENCE INC. 2000-12-19 US disclosed
WO-1999041227-A1 TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-08-19 WO disclosed