Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PTPRCAP | Q14761 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345733 | 0.82 | HTR1A (0.63) | HTR1ADRD2DRD3HTR2CHTR2A | |
| SCHEMBL10949931 | 0.74 | PRCP (0.37) | PRCPHTR1ADRD2DRD3HTR2C | |
| SCHEMBL11066183 | 0.71 | NPSR1 (0.49) | HTR1ADRD2HTR2CHTR2AHTR2B | |
| SCHEMBL7493270 | 0.71 | HTR2C (0.43) | PRCPHTR1ADRD2DRD3HTR2C | |
| SCHEMBL3119365 | 0.67 | PRCP (1.00) | PRCP | |
| SCHEMBL31424178 | 0.67 | PRCP (1.00) | PRCP | |
| SCHEMBL14301431 | 0.64 | PRCP (0.39) | PRCPHTR1AHTR2A | |
| SCHEMBL2305931 | 0.63 | PARP1 (0.63) | HTR1ADRD2DRD3HTR2CHTR2A | |
| SCHEMBL24017135 | 0.63 | HTR2A (0.43) | PRCPHTR2A | |
| SCHEMBL24017113 | 0.63 | HTR2A (0.43) | PRCPHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0216072-B1 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1992-08-26 | — | — | EP | claimed |
| US-4795759-A | PREVENTION ALCOHOLISM | SANDOZ LTD. (CH) | 1989-01-03 | — | — | US | claimed |
| EP-0216072-A2 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1987-04-01 | — | — | EP | claimed |
| EP-0216072-B1 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1992-08-26 | — | — | EP | disclosed |
| US-4795759-A | PREVENTION ALCOHOLISM | SANDOZ LTD. (CH) | 1989-01-03 | — | — | US | disclosed |
| US-4795759-A | PREVENTION ALCOHOLISM | SANDOZ LTD. (CH) | 1989-01-03 | — | — | US | disclosed |
| EP-0216072-A2 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1987-04-01 | — | — | EP | disclosed |
| EP-0216072-A2 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1987-04-01 | — | — | EP | disclosed |
| US-4602032-A | Dibenz[cd,f]indole derivatives, their preparation and pharmaceutical compositions containing them | SANDOZ LTD. (CH) | 1986-07-22 | — | — | US | disclosed |