Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tranexamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG known ✓ | P00747 | 1/20 | 0.95 |
| ▸ | PLAT | P00750 | 1/20 | 0.95 |
| ▸ | LMNA | P02545 | 1/20 | 0.95 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tranexamic Acid SCHEMBL11189660 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL10723475 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL10972769 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL3793503 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL7323218 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL10723480 | 1.00 | PLG (0.95) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL322487 | 0.98 | PLG (1.00) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL16974 | 0.98 | PLG (1.00) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL186034 | 0.98 | PLG (1.00) | PLGPLATLMNAANPEPENPEP | |
| Tranexamic Acid SCHEMBL423790 | 0.98 | PLG (1.00) | PLGPLATLMNAANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117603080-A | Preparation method of tranexamic acid impurity | 常州寅盛药业有限公司 | 2024-02-27 | — | — | CN | claimed |
| EP-2801348-B1 | ORAL WASHING COMPOSITION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASES | HAYASHIBARA CO (JP) | 2019-05-22 | — | — | EP | claimed |
| US-9295627-B2 | Mouthwash composition for preventing and/or treating periodontal diseases | Hayashibara Co., Ltd. (JP) | 2016-03-29 | — | — | US | claimed |
| US-4071553-A | Method for the production of trans-4-aminomethyl cyclohexane-1-carboxylic acid | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1978-01-31 | — | — | US | claimed |
| JP-6072975-A | — | — | None | — | — | JP | disclosed |
| CN-117603080-A | Preparation method of tranexamic acid impurity | 常州寅盛药业有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117603080-A | Preparation method of tranexamic acid impurity | 常州寅盛药业有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-113943259-A | Amino acid derivative, preparation method and application thereof | 西安禾渼生物医药有限公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-113365601-A | Composition for external application to skin | 日本乐敦制药株式会社 | 2021-09-07 | — | — | CN | disclosed |
| WO-2020158908-A1 | TOPICAL COMPOSITION | ロート製薬株式会社 | 2020-08-06 | — | — | WO | disclosed |
| EP-2801348-B1 | ORAL WASHING COMPOSITION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASES | HAYASHIBARA CO (JP) | 2019-05-22 | — | — | EP | disclosed |
| US-9295627-B2 | Mouthwash composition for preventing and/or treating periodontal diseases | Hayashibara Co., Ltd. (JP) | 2016-03-29 | — | — | US | disclosed |
| US-20140356298-A1 | MOUTHWASH COMPOSITION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASES | Hayashibara Co., Ltd. (JP) | 2014-12-04 | — | — | US | disclosed |
| EP-2801348-A1 | ORAL WASHING COMPOSITION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASES | Hayashibara Co., Ltd. (JP) | 2014-11-12 | — | — | EP | disclosed |
| JP-H0672975-A | TRANEXAMIC ACID DIMER, ITS SALT AND EXTERNAL MEDICINE FOR SKIN CONTAINING THE SAME | SHISEIDO CO LTD | 1994-03-15 | — | — | JP | disclosed |
| EP-0044541-B1 | AMINOCARBOXYLIC ACIDS, AMINO ALCOHOLS, OR THE DERIVATIVES THEREOF, PROCESSES FOR PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION, CONTAINING AT LEAST ONE OF THESE COMPOUNDS | TEIJIN LIMITED (JP) | 1983-09-21 | — | — | EP | disclosed |
| US-4402975-A | ANTIULCER AGENTS | TEIJIN LIMITED (JP) | 1983-09-06 | — | — | US | disclosed |
| EP-0044541-A1 | Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds | TEIJIN LIMITED (JP) | 1982-01-27 | — | — | EP | disclosed |
| US-4071553-A | Method for the production of trans-4-aminomethyl cyclohexane-1-carboxylic acid | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1978-01-31 | — | — | US | disclosed |
| US-3950405-A | ANTIPLASMIN AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) | 1976-04-13 | — | — | US | disclosed |