Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.61 |
| ▸ | YAP1 | P46937 | 3/20 | 0.57 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.54 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | STS | P08842 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358504 | 0.91 | YAP1 (0.65) | GPR119YAP1TEAD1TEAD3KDM4E | |
| SCHEMBL2158159 | 0.91 | GPR119 (0.65) | GPR119YAP1TEAD1TEAD3KDM4E | |
| SCHEMBL23453749 | 0.90 | GPR119 (0.60) | GPR119YAP1CHEK2 | |
| SCHEMBL23453711 | 0.90 | GPR119 (0.60) | GPR119YAP1CHEK2 | |
| SCHEMBL944418 | 0.86 | GPR119 (0.57) | GPR119YAP1TEAD1TEAD3KDM4E | |
| SCHEMBL16385072 | 0.85 | GPR119 (0.67) | GPR119TEAD1TEAD3KDM4EPKM | |
| SCHEMBL13335340 | 0.85 | GPR119 (0.70) | GPR119CHEK2 | |
| SCHEMBL22436046 | 0.84 | GPR119 (0.61) | GPR119YAP1CHEK2 | |
| SCHEMBL7373950 | 0.84 | GPR119 (0.63) | GPR119TEAD1TEAD3CHEK2 | |
| SCHEMBL4322579 | 0.84 | GPR119 (0.65) | GPR119STSCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |