Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 4/20 | 0.34 |
| ▸ | PEPD | P12955 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326668 | 0.86 | CASP3 (0.36) | ACECASP3KMT2A | |
| SCHEMBL7327045 | 0.83 | ACE (0.49) | ACEMME | |
| SCHEMBL7323145 | 0.80 | CASP3 (0.36) | ACECASP3KMT2A | |
| SCHEMBL10201316 | 0.77 | FKBP1A (0.41) | POLBFKBP1AACEPEPDBRD4 | |
| SCHEMBL1490176 | 0.76 | ACE (0.40) | POLBFKBP1AACEPEPDBRD4 | |
| SCHEMBL10201668 | 0.76 | FKBP1A (0.38) | POLBFKBP1AACEPEPDBRD4 | |
| SCHEMBL10663842 | 0.76 | ACE (0.40) | POLBFKBP1AACEPEPDBRD4 | |
| SCHEMBL7427663 | 0.75 | ACE (0.33) | ACE | |
| SCHEMBL10201670 | 0.73 | FKBP1A (0.36) | POLBFKBP1AACEPEPDBRD4 | |
| SCHEMBL10669987 | 0.73 | ACE (0.48) | POLBFKBP1AACEPEPDBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785093-A | Bicyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 1988-11-15 | — | — | US | claimed |
| US-4826980-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-05-02 | — | — | US | disclosed |
| US-4785093-A | Bicyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 1988-11-15 | — | — | US | disclosed |
| US-4762924-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1988-08-09 | — | — | US | disclosed |
| US-4743687-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1988-05-10 | — | — | US | disclosed |
| US-4692438-A | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity | HOFFMANN-LA ROCHE INC. (US) | 1987-09-08 | — | — | US | disclosed |