Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326492 | 1.00 | MCL1 (0.54) | MCL1ALBPLA2G4AGRIN2DGRIN3B | |
| SCHEMBL29247884 | 0.87 | GRIN2D (0.51) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL16756075 | 0.86 | RAB9A (0.51) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3204520 | 0.86 | ALB (0.49) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL3204531 | 0.86 | ALB (0.49) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7968178 | 0.83 | MCL1 (0.57) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6364609 | 0.83 | ALB (0.47) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6364611 | 0.83 | ALB (0.47) | MCL1ALBGRIN2DGRIN3BGRIN1 | |
| SCHEMBL19100040 | 0.80 | MCL1 (0.57) | MCL1ALBPLA2G4AKMT2AMEN1 | |
| SCHEMBL7135266 | 0.80 | TTR (0.45) | MCL1ALBGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0392663-A1 | Carboline derivative as a 5-HT3 receptor antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-10-17 | — | — | EP | disclosed |