Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326498 | 1.00 | HTR2A (0.41) | HTR2AESR1ADRA2AADORA3TACR2 | |
| SCHEMBL7335148 | 0.96 | HTR2A (0.40) | HTR2AESR1ADRA2AADORA3TACR2 | |
| Hydrochloric Acid SCHEMBL11741516 | 0.95 | HTR2A (0.39) | HTR2AESR1ADRA2AADORA3TACR2 | |
| Hydrochloric Acid SCHEMBL11745517 | 0.95 | HTR2A (0.39) | HTR2AESR1ADRA2AADORA3TACR2 | |
| Hydrochloric Acid SCHEMBL11741356 | 0.80 | SLC2A1 (0.41) | HSD17B10LMNATP53TSHR | |
| SCHEMBL11775570 | 0.79 | CTSD (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1NISCH | |
| Hydrochloric Acid SCHEMBL11737896 | 0.78 | MAOA (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1NISCH | |
| Hydrochloric Acid SCHEMBL11776520 | 0.78 | MAOA (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1NISCH | |
| SCHEMBL9719255 | 0.75 | PSEN1 (0.39) | HTR2ASLC6A2SLC6A4SLC6A3HSD17B10 | |
| SCHEMBL11774463 | 0.75 | PSEN1 (0.39) | HTR2ASLC6A2SLC6A4SLC6A3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198433-A | Hypotensive | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5158945-A | Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0370320-B1 | LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-30 | — | — | EP | disclosed |
| US-5128337-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5082837-A | Hypotensive | MERRELL DOW PHARMACEUTICALS (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010072-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0370320-A1 | Lactamimides in the treatment of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-30 | — | — | EP | disclosed |
| EP-0348891-A2 | Lactamimides as calcium antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4061746-A | Lactamimide inhibitors of gastrointestinal hypersecretion | RICHARDSON-MERRELL INC. (US) | 1977-12-06 | — | — | US | disclosed |