Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317573 | 0.88 | HDAC8 (0.64) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL14684392 | 0.88 | HDAC8 (0.64) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL7320811 | 0.87 | CAPN1 (0.62) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7325949 | 0.86 | CTSL (0.49) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL7316192 | 0.86 | CAPN1 (0.57) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7326079 | 0.84 | HDAC8 (0.58) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL7326086 | 0.84 | HDAC8 (0.60) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL9716778 | 0.83 | ATM (0.67) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL7044299 | 0.83 | ATM (0.67) | HDAC8ITGB3ITGA2BF2CTSL | |
| SCHEMBL9716776 | 0.83 | ATM (0.67) | HDAC8ITGB3ITGA2BF2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |