Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.53 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9442931 | 1.00 | REN (0.57) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL9442952 | 1.00 | REN (0.57) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL8861579 | 0.91 | ITGA4 (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL9069632 | 0.91 | ITGA4 (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL9069634 | 0.91 | ITGA4 (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL7388993 | 0.90 | REN (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL7316102 | 0.90 | REN (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL10448523 | 0.90 | REN (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL7380187 | 0.88 | REN (0.58) | RENPOLBMAPTTDP1ATM | |
| SCHEMBL9443008 | 0.88 | REN (0.58) | RENPOLBMAPTTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A4 | NON-PEPTIDE RENIN INHIBITORS | — | 1991-11-06 | — | — | EP | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |