Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436607 | 1.00 | ACE (0.43) | ACEPIN1GAAHPGDATM | |
| SCHEMBL11106544 | 0.88 | GAA (0.42) | ACEPIN1GAAHPGDATM | |
| SCHEMBL11106542 | 0.88 | GAA (0.42) | ACEPIN1GAAHPGDATM | |
| SCHEMBL10811569 | 0.81 | ACE (0.43) | ACEGAAHPGDATMSMN1; SMN2 | |
| SCHEMBL10808452 | 0.81 | ACE (0.43) | ACEGAAHPGDATMSMN1; SMN2 | |
| SCHEMBL7424201 | 0.78 | LMNA (0.38) | HPGD | |
| SCHEMBL10808951 | 0.78 | BACE1 (0.42) | GAAHPGDATMSMN1; SMN2L3MBTL1 | |
| SCHEMBL11106553 | 0.78 | GAA (0.42) | PIN1GAAHPGDATMSMN1; SMN2 | |
| SCHEMBL11106548 | 0.78 | GAA (0.39) | PIN1GAAHPGDATMSMN1; SMN2 | |
| SCHEMBL7326888 | 0.77 | ACE (0.52) | ACEPIN1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120728-A1 | Thiazine and thiazepine containing compounds | E.R. Squibb & Sons, Inc. (US) | 1984-10-03 | — | — | EP | disclosed |
| US-4460579-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-17 | — | — | US | disclosed |