Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.53 |
| ▸ | GRM8 | O00222 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732695 | 1.00 | MAPT (0.53) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL8579653 | 1.00 | MAPT (0.53) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL2942139 | 0.88 | TSHR (0.50) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2942137 | 0.88 | TSHR (0.50) | MAPTHTTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11460934 | 0.86 | VCAM1 (0.51) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL732920 | 0.84 | MAPT (0.50) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL730853 | 0.83 | GRM8 (0.55) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL4072082 | 0.83 | GRM8 (0.55) | MAPTMEN1HTTKMT2ACYP1A2 | |
| SCHEMBL18458413 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2ACYP1A2CYP2D6AKR1C3 | |
| SCHEMBL286995 | 0.83 | GRM8 (0.50) | MAPTKMT2ACYP2C19GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138335-B2 | Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD (JP) | 2012-03-20 | — | — | US | disclosed |