Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 10/20 | 0.44 |
| ▸ | HRH1 | P35367 | 8/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4998895 | 0.84 | HTR2A (0.49) | CES2HTR2AHRH1HTR2CKDM4E | |
| SCHEMBL7196338 | 0.82 | ANPEP (0.52) | HTR2AHRH1HTR2CANPEP | |
| SCHEMBL9719421 | 0.80 | CYP19A1 (0.56) | HTR2AHRH1HTR2CANPEP | |
| SCHEMBL8651685 | 0.76 | HTR2A (0.39) | CES2HTR2AHRH1HTR2CMCHR1 | |
| SCHEMBL7327997 | 0.76 | HTR2A (0.39) | CES2HTR2AHRH1HTR2CMCHR1 | |
| SCHEMBL8651365 | 0.76 | HTR2A (0.39) | CES2HTR2AHRH1HTR2CMCHR1 | |
| SCHEMBL6823777 | 0.75 | HTR2A (0.45) | CES2HTR2AHRH1HTR2CANPEP | |
| SCHEMBL7331623 | 0.73 | ANPEP (0.42) | HTR2AHRH1HTR2CANPEPOPRD1 | |
| SCHEMBL9248071 | 0.73 | ANPEP (0.57) | HTR2AHRH1HTR2CANPEPSMN1; SMN2 | |
| SCHEMBL6823296 | 0.73 | HTR2A (0.50) | HTR2AHRH1HTR2CANPEPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0711271-A1 | AMINOINDANES AND RELATED COMPOUNDS USEFUL AS CALCIUM-CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004027-A1 | AMINOINDANES AND RELATED COMPOUNDS USEFUL AS CALCIUM-CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-09 | — | — | WO | disclosed |