Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 16/20 | 0.47 |
| ▸ | CTSE | P14091 | 7/20 | 0.45 |
| ▸ | CTSD | P07339 | 6/20 | 0.45 |
| ▸ | PGA5 | P0DJD9 | 4/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PGC | P20142 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327167 | 0.82 | REN (0.50) | RENCTSECTSD | |
| SCHEMBL3347419 | 0.80 | PSEN1 (0.39) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL967760 | 0.80 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL970762 | 0.80 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL969137 | 0.80 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL968972 | 0.79 | CYP2D6 (0.42) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7312864 | 0.79 | PSEN1 (0.38) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL968973 | 0.79 | CYP2D6 (0.42) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3382250 | 0.79 | PSEN1 (0.37) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1862727 | 0.79 | LTA4H (0.43) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198426-A | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0380805-A1 | Renin inhibitors containing C-terminal dihydroxy amides | WARNER-LAMBERT COMPANY (US) | 1990-08-08 | — | — | EP | disclosed |
| WO-1990007521-A1 | RENIN INHIBITORS CONTAINING C-TERMINAL DIHYDROXY AMIDES | WARNER-LAMBERT COMPANY (US) | 1990-07-12 | — | — | WO | disclosed |