Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.61 |
| ▸ | DRD3 | P35462 | 8/20 | 0.61 |
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 6/20 | 0.61 |
| ▸ | DRD5 | P21918 | 4/20 | 0.61 |
| ▸ | DRD1 | P21728 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7327779 | 0.92 | MEN1 (0.54) | DRD2DRD3HTR1AHTR2ADRD5 | |
| Hydrochloric Acid SCHEMBL7326824 | 0.87 | DRD3 (0.52) | DRD2DRD3HTR1AHTR2ADRD5 | |
| Hydrochloric Acid SCHEMBL7319716 | 0.85 | SLC6A3 (0.47) | DRD2DRD3HTR1AHTR2ADRD5 | |
| SCHEMBL9143010 | 0.84 | MAPT (0.56) | DRD2DRD3HTR1AHTR2ADRD5 | |
| SCHEMBL5026310 | 0.84 | KCNH2 (0.53) | DRD2DRD3HTR1AHTR2ADRD5 | |
| Hydrochloric Acid SCHEMBL7318462 | 0.82 | KCNH2 (0.49) | DRD2DRD3HTR1AHTR2ADRD5 | |
| SCHEMBL10334811 | 0.77 | SCN5A (0.58) | DRD2DRD3HTR1AHTR2ADRD5 | |
| SCHEMBL9140855 | 0.77 | MAPT (0.62) | DRD2DRD3HTR1AHTR2ADRD5 | |
| Hydrochloric Acid SCHEMBL11811594 | 0.75 | DRD2 (0.70) | DRD2DRD3HTR1AHTR2ADRD5 | |
| SCHEMBL904905 | 0.75 | DRD2 (0.83) | DRD2DRD3HTR1AHTR2ADRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933346-A | CARDIOVASCULAR AND CEREBROVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |
| EP-0290958-A2 | Diarylalkyl-substituted alkylamines, process for their preparation, their use as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-17 | — | — | EP | disclosed |