Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | YAP1 | P46937 | 3/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.47 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357696 | 0.92 | YAP1 (0.55) | CHEK2HTR6BCHEACKR3YAP1 | |
| SCHEMBL3443784 | 0.91 | CHEK2 (0.56) | USP30CHEK2HTR6BCHEACKR3 | |
| SCHEMBL3443787 | 0.91 | CHEK2 (0.56) | USP30CHEK2HTR6BCHEACKR3 | |
| SCHEMBL7356793 | 0.86 | CHEK2 (0.60) | USP30CHEK2ACKR3ALOX5APFEN1 | |
| SCHEMBL17729089 | 0.85 | CHEK2 (0.56) | CHEK2HTR6BCHEACKR3ALOX5AP | |
| SCHEMBL1769253 | 0.85 | CHEK2 (0.56) | CHEK2HTR6BCHEACKR3ALOX5AP | |
| SCHEMBL13876978 | 0.84 | KDM4E (0.56) | USP30YAP1 | |
| SCHEMBL23250048 | 0.83 | YAP1 (0.50) | CHEK2HTR6BCHEYAP1PRMT5 | |
| SCHEMBL23250074 | 0.83 | YAP1 (0.50) | CHEK2HTR6BCHEYAP1PRMT5 | |
| SCHEMBL3323958 | 0.83 | HTR6 (0.54) | USP30HTR6BCHEACKR3YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674514-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013291-A1 | USE OF ARYLOXYALKYL SUBSTITUTED CYCLIC AMINES AS CALCIUM CHANNEL ANTAGONISTS AND NEW PHENYLOXYALKYL PIPERIDIN DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1994-06-23 | — | — | WO | disclosed |