Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 5/20 | 0.57 |
| ▸ | CTSS | P25774 | 2/20 | 0.57 |
| ▸ | CTSK | P43235 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 2/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315385 | 1.00 | PSMB5 (0.58) | PSMB5CTSLCTSSCTSKPTPN1 | |
| SCHEMBL10119250 | 0.92 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKPTPN1 | |
| SCHEMBL7318555 | 0.92 | PSMB5 (0.65) | PSMB5CTSLCTSSCTSKPTPN1 | |
| SCHEMBL7315389 | 0.90 | PSMB5 (0.60) | PSMB5CTSLCTSSCTSKLTA4H | |
| SCHEMBL10119263 | 0.86 | CTSS (0.60) | PSMB5CTSLCTSSCTSKMME | |
| SCHEMBL10118946 | 0.86 | CTSS (0.67) | PSMB5CTSLCTSSCTSKPTPN1 | |
| SCHEMBL14297648 | 0.86 | CTSS (0.60) | PSMB5CTSLCTSSCTSKMME | |
| SCHEMBL9818634 | 0.85 | CAPN1 (0.47) | PSMB5LTA4HMMEACE | |
| SCHEMBL14297659 | 0.84 | PSMB5 (0.56) | PSMB5CTSLCTSSCTSKLTA4H | |
| SCHEMBL12516880 | 0.84 | PSMB5 (0.56) | PSMB5CTSLCTSSCTSKLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272671-B1 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD (CH) | 1994-03-16 | — | — | EP | disclosed |
| US-5158936-A | Treating or prevention of tissue damage, inflammation, bone resporpption and muscular dystrophy | SYNTEX (U.S.A.) INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055451-A | Prevent tissue damage | SYNTEX INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0272671-A2 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors | SANDOZ LTD. (CH) | 1988-06-29 | — | — | EP | disclosed |