SCHEMBL7327733

SCHEMBL7327733

Clc1ccc(C(N=C2CCCCCN2)c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 7/20 0.36
SLC6A4 P31645 7/20 0.36
SLC6A3 Q01959 7/20 0.36
IDO1 P14902 2/20 0.35
TDO2 P48775 2/20 0.35
CYP3A4 P08684 3/20 0.35
CHRM2 P08172 3/20 0.35
HTR1A P08908 3/20 0.35
ADRA2A P08913 3/20 0.35
CHRM1 P11229 3/20 0.35
DRD1 P21728 3/20 0.35
TBXA2R P21731 3/20 0.35
ADRA1A P35348 3/20 0.35
DRD3 P35462 3/20 0.35
KCNH2 Q12809 3/20 0.35
CYP2D6 P10635 3/20 0.35
OPRM1 P35372 2/20 0.35
TSHR P16473 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11873137 0.99 IDO1 (0.36) SLC6A2SLC6A4SLC6A3IDO1TDO2
SCHEMBL9719292 0.94 SLC6A2 (0.36) SLC6A2SLC6A4SLC6A3CYP2D6ALDH1A1
SCHEMBL9719290 0.94 SLC6A2 (0.36) SLC6A2SLC6A4SLC6A3CYP2D6ALDH1A1
SCHEMBL7332379 0.94 SLC6A2 (0.36) SLC6A2SLC6A4SLC6A3CYP2D6ALDH1A1
Hydrochloric Acid SCHEMBL11879766 0.93 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3CYP2D6CYP19A1
SCHEMBL7327602 0.91 NPC1 (0.33) CYP3A4KCNH2CYP2D6CYP2C19CYP1A2
SCHEMBL7325274 0.91 NPC1 (0.33) CYP3A4KCNH2CYP2D6CYP2C19CYP1A2
SCHEMBL7327606 0.91 NPC1 (0.33) CYP3A4KCNH2CYP2D6CYP2C19CYP1A2
SCHEMBL7328837 0.91 NPC1 (0.33) CYP3A4KCNH2CYP2D6CYP2C19CYP1A2
SCHEMBL7325279 0.91 NPC1 (0.33) CYP3A4KCNH2CYP2D6CYP2C19CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3963701-A DIURETIC, ANTICOAGULANT RICHARDSON-MERRELL INC. (US) 1976-06-15 US claimed
US-5198433-A Hypotensive MERRELL DOW PHARMACEUTICALS INC. (US) 1993-03-30 US disclosed
US-5158945-A Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1992-10-27 US disclosed
EP-0370320-B1 LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS MERRELL DOW PHARMACEUTICALS INC. (US) 1992-09-30 EP disclosed
US-5128337-A Hypotensive agents MERRELL DOW PHARMACEUTICALS INC. (US) 1992-07-07 US disclosed
US-5082837-A Hypotensive MERRELL DOW PHARMACEUTICALS (US) 1992-01-21 US disclosed
US-5010072-A Hypotensive agents MERRELL DOW PHARMACEUTICALS INC. (US) 1991-04-23 US disclosed
EP-0370320-A1 Lactamimides in the treatment of drug-resistant protozoal infections MERRELL DOW PHARMACEUTICALS INC. (US) 1990-05-30 EP disclosed
EP-0348891-A2 Lactamimides as calcium antagonists MERRELL DOW PHARMACEUTICALS INC. (US) 1990-01-03 EP disclosed
US-4061746-A Lactamimide inhibitors of gastrointestinal hypersecretion RICHARDSON-MERRELL INC. (US) 1977-12-06 US disclosed
US-3963701-A DIURETIC, ANTICOAGULANT RICHARDSON-MERRELL INC. (US) 1976-06-15 US disclosed