Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327602 | 1.00 | NPC1 (0.33) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7325279 | 1.00 | NPC1 (0.33) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7325274 | 1.00 | NPC1 (0.33) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL7327606 | 1.00 | NPC1 (0.33) | NPC1HPGDRAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL11875818 | 0.91 | HTR2A (0.36) | MEN1KMT2A | |
| SCHEMBL7327733 | 0.91 | SLC6A2 (0.36) | HPGDSMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7336045 | 0.91 | HTR2A (0.36) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11872449 | 0.91 | CHRNB2 (0.33) | NPC1HPGDSMN1; SMN2CYP3A4KCNH2 | |
| SCHEMBL7336042 | 0.91 | HTR2A (0.36) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11879426 | 0.90 | HTR2A (0.35) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5198433-A | Hypotensive | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5158945-A | Cardiotonic agents, vasodilators, hypotensive agents, anticonvulsants, antiisichemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0370320-B1 | LACTAMIMIDES IN THE TREATMENT OF DRUG-RESISTANT PROTOZOAL INFECTIONS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-30 | — | — | EP | disclosed |
| US-5128337-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-07 | — | — | US | disclosed |
| US-5082837-A | Hypotensive | MERRELL DOW PHARMACEUTICALS (US) | 1992-01-21 | — | — | US | disclosed |
| US-5010072-A | Hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0370320-A1 | Lactamimides in the treatment of drug-resistant protozoal infections | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-30 | — | — | EP | disclosed |
| EP-0348891-A2 | Lactamimides as calcium antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4061746-A | Lactamimide inhibitors of gastrointestinal hypersecretion | RICHARDSON-MERRELL INC. (US) | 1977-12-06 | — | — | US | disclosed |