Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | DHPS | P49366 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326214 | 0.86 | NR1H2 (0.40) | NR1H2MCL1BCL2L1PGRKEAP1 | |
| SCHEMBL7321798 | 0.83 | GBA1 (0.40) | EDNRAEDNRBNR1H2DHPSMCL1 | |
| SCHEMBL8327618 | 0.82 | EDNRA (0.42) | EDNRAEDNRBNR1H2DHPSMCL1 | |
| SCHEMBL7598526 | 0.81 | KMT2A (0.40) | EDNRAEDNRBNR1H2KEAP1NFE2L2 | |
| SCHEMBL7333240 | 0.79 | EDNRA (0.50) | EDNRAEDNRBDHPSNR1I2 | |
| SCHEMBL7322839 | 0.77 | EDNRA (0.42) | EDNRAEDNRBNR1H2DHPSMCL1 | |
| SCHEMBL8326451 | 0.76 | EDNRA (0.41) | EDNRAEDNRBMCL1BCL2L1MEN1 | |
| SCHEMBL7330749 | 0.75 | EDNRA (0.49) | EDNRAEDNRBDHPSNR1I2 | |
| SCHEMBL7329858 | 0.74 | EDNRA (0.62) | EDNRAEDNRBDHPSNR1I2 | |
| SCHEMBL8321015 | 0.74 | EDNRA (0.45) | EDNRAEDNRBNR1H2MCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | claimed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | claimed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |