Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.42 |
| ▸ | EDNRB | P24530 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DHPS | P49366 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322839 | 0.90 | EDNRA (0.42) | EDNRAEDNRBMAPTPOLBDHPS | |
| SCHEMBL8325946 | 0.88 | MAPT (0.38) | MAPTPOLBMEN1KMT2AGAA | |
| SCHEMBL8321015 | 0.87 | EDNRA (0.45) | EDNRAEDNRBMAPTPOLBMEN1 | |
| SCHEMBL7331086 | 0.84 | EDNRA (0.36) | EDNRAEDNRBMAPTPOLBMEN1 | |
| SCHEMBL7327693 | 0.84 | EDNRA (0.37) | EDNRAEDNRBPOLBMEN1KMT2A | |
| SCHEMBL7327772 | 0.82 | EDNRA (0.42) | EDNRAEDNRBDHPSMEN1KMT2A | |
| SCHEMBL7010894 | 0.80 | MCL1 (0.38) | EDNRAEDNRBMAPTPOLBMEN1 | |
| SCHEMBL7332509 | 0.80 | RORC (0.38) | MAPTPOLBMEN1KMT2AGAA | |
| SCHEMBL7333240 | 0.80 | EDNRA (0.50) | EDNRAEDNRBDHPS | |
| SCHEMBL8326182 | 0.79 | EDNRB (0.45) | EDNRAEDNRBMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |