Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327772 | 0.81 | EDNRA (0.42) | KMT2AKEAP1NFE2L2SMN1; SMN2HPGD | |
| SCHEMBL7321798 | 0.78 | GBA1 (0.40) | KMT2AALDH1A1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL8326904 | 0.77 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL7598517 | 0.75 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL7322839 | 0.73 | EDNRA (0.42) | KMT2AHPGDEDNRAEDNRBNR1H2 | |
| SCHEMBL8326008 | 0.72 | EDNRA (0.47) | KMT2AKEAP1NFE2L2ALDH1A1HPGD | |
| SCHEMBL7327055 | 0.71 | EDNRA (0.48) | EDNRAEDNRB | |
| SCHEMBL8326451 | 0.71 | EDNRA (0.41) | KMT2AALDH1A1CYP2C9HPGDEDNRA | |
| SCHEMBL8327618 | 0.71 | EDNRA (0.42) | KMT2AEDNRAEDNRBNR1H2MAPT | |
| SCHEMBL7330749 | 0.71 | EDNRA (0.49) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768304-B1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | HOFFMANN LA ROCHE (CH) | 2002-05-22 | — | — | EP | disclosed |