Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9617094 | 0.93 | HTR3A (0.39) | GAAPKMSMN1; SMN2MAPK1POLB | |
| Fumaric Acid SCHEMBL7331885 | 0.89 | SMN1; SMN2 (0.48) | GAASMN1; SMN2MAPK1POLBLMNA | |
| Fumaric Acid SCHEMBL7330519 | 0.87 | SMN1; SMN2 (0.49) | GAAPKMSMN1; SMN2LMNATSHR | |
| Fumaric Acid SCHEMBL7335420 | 0.87 | KMT2A (0.43) | PKMSMN1; SMN2MAPK1POLBLMNA | |
| Fumaric Acid SCHEMBL7325579 | 0.86 | GAA (0.55) | GAAPKMSMN1; SMN2POLBTSHR | |
| SCHEMBL7327894 | 0.83 | BRD4 (0.47) | GAAPKMSMN1; SMN2MAPK1POLB | |
| SCHEMBL7327002 | 0.83 | SMN1; SMN2 (0.53) | GAASMN1; SMN2MAPK1POLBLMNA | |
| Fumaric Acid SCHEMBL7334775 | 0.82 | POLB (0.38) | POLBMEN1KMT2AALDH1A1HPGD | |
| Fumaric Acid SCHEMBL7331898 | 0.82 | SMN1; SMN2 (0.48) | GAASMN1; SMN2MAPK1POLBLMNA | |
| SCHEMBL7328287 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNATSHRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4009372-A | — | — | None | — | — | JP | disclosed |
| JP-H049372-A | 4,5,6,7-TETRAHYDROBENZIMIDAZOLE DERIVATIVE | YAMANOUCHI PHARMACEUT CO LTD | 1992-01-14 | — | — | JP | disclosed |