Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 10/20 | 0.48 |
| ▸ | DHPS | P49366 | 10/20 | 0.46 |
| ▸ | EDNRB | P24530 | 6/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302671 | 0.90 | EDNRA (0.43) | EDNRADHPSEDNRB | |
| SCHEMBL7321798 | 0.89 | GBA1 (0.40) | EDNRADHPSEDNRB | |
| SCHEMBL7331793 | 0.88 | EDNRA (0.49) | EDNRADHPSEDNRB | |
| SCHEMBL7329858 | 0.88 | EDNRA (0.62) | EDNRADHPSEDNRBABCC3ABCC4 | |
| SCHEMBL7327165 | 0.86 | EDNRA (0.53) | EDNRADHPSEDNRBABCC3ABCC4 | |
| SCHEMBL7300166 | 0.85 | DHPS (0.38) | EDNRADHPSEDNRB | |
| SCHEMBL7330749 | 0.84 | EDNRA (0.49) | EDNRADHPSEDNRBABCC3ABCC4 | |
| SCHEMBL7328712 | 0.84 | EDNRA (0.48) | EDNRADHPSEDNRB | |
| SCHEMBL7332438 | 0.84 | EDNRA (0.48) | EDNRADHPSEDNRBABCC3ABCC4 | |
| SCHEMBL7333240 | 0.84 | EDNRA (0.50) | EDNRADHPSEDNRBABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | claimed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | claimed |
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |