Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 5/20 | 0.38 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301570 | 0.87 | GBA1 (0.43) | MEN1KMT2AGBA1RORC | |
| SCHEMBL7303989 | 0.87 | DHPS (0.47) | DHPSEDNRAEDNRB | |
| SCHEMBL7297143 | 0.86 | DHPS (0.42) | DHPSEDNRARORC | |
| SCHEMBL7302917 | 0.86 | EDNRA (0.51) | DHPSEDNRAEDNRB | |
| SCHEMBL7328142 | 0.85 | EDNRA (0.48) | DHPSEDNRAEDNRB | |
| SCHEMBL8322432 | 0.84 | LMNA (0.41) | DHPSMEN1KMT2ANPSR1EDNRA | |
| SCHEMBL7293765 | 0.83 | EDNRA (0.44) | DHPSMEN1KMT2AEDNRA | |
| SCHEMBL7302671 | 0.83 | EDNRA (0.43) | DHPSMEN1KMT2ANPSR1EDNRA | |
| SCHEMBL7302684 | 0.83 | DHPS (0.38) | DHPSEDNRARORC | |
| SCHEMBL7292782 | 0.83 | EDNRA (0.40) | DHPSMEN1KMT2ANPSR1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |