⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27885318 | 0.79 | — | — | |
| SCHEMBL9015917 | 0.79 | EHMT2 (0.35) | — | |
| SCHEMBL3725338 | 0.75 | — | — | |
| SCHEMBL10848409 | 0.75 | — | — | |
| SCHEMBL135572 | 0.75 | — | — | |
| SCHEMBL28006177 | 0.75 | — | — | |
| SCHEMBL27885321 | 0.73 | — | — | |
| SCHEMBL28189487 | 0.71 | — | — | |
| SCHEMBL9256751 | 0.70 | ALDH1A1 (0.36) | — | |
| SCHEMBL726340 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733055-A1 | 2-SPIRO(2'-SPIROCYCLOALKYL)CYCLOPROPYL CEPHALOSPORIN SULFONES AS ANTIINFLAMMATORY AND ANTIDEGENERATIVE AGENTS | SYNPHAR LABORATORIES INC. (CA) | 1996-09-25 | — | — | EP | disclosed |
| US-5439904-A | Enzyme inhibitors of human leukocyte elastase; respiratory system disorders; antiarthritic agents | SYNPHAR LABORATORIES, INC. (CA) | 1995-08-08 | — | — | US | disclosed |
| WO-1995015966-A1 | 2-SPIRO(2'-SPIROCYCLOALKYL)CYCLOPROPYL CEPHALOSPORIN SULFONES AS ANTIINFLAMMATORY AND ANTIDEGENERATIVE AGENTS | SYNPHAR LABORATORIES, INC. (CA) | 1995-06-15 | — | — | WO | disclosed |