Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | DRD3 | P35462 | 4/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.56 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RB1 | P06400 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7331688 | 0.99 | DRD2 (0.60) | DRD2DRD3GRIN2BSLC18A3CA1 | |
| SCHEMBL8671620 | 0.91 | GRIN2B (0.56) | DRD2DRD3GRIN2BSLC18A3MTNR1A | |
| SCHEMBL7327888 | 0.89 | GRIN2B (0.58) | DRD2DRD3GRIN2BSLC18A3CA1 | |
| Hydrochloric Acid SCHEMBL9593059 | 0.89 | DRD2 (0.47) | DRD2DRD3GRIN2BSLC18A3CA1 | |
| Hydrochloric Acid SCHEMBL7335303 | 0.88 | GRIN2B (0.57) | DRD2DRD3GRIN2BSLC18A3CA1 | |
| SCHEMBL7326879 | 0.87 | GRIN2B (0.60) | DRD2DRD3GRIN2BDRD4 | |
| Hydrochloric Acid SCHEMBL7336666 | 0.86 | GRIN2B (0.59) | DRD2DRD3GRIN2BDRD4 | |
| SCHEMBL7336034 | 0.85 | DRD2 (0.57) | DRD2DRD3SLC18A3CA1CA2 | |
| Hydrochloric Acid SCHEMBL7328559 | 0.85 | GRIN2B (0.60) | GRIN2B | |
| Hydrochloric Acid SCHEMBL7326697 | 0.85 | GRIN2B (0.60) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5196454-A | METHOD OF TREATING DISORDERS OF THE DOPAMINERGIC SYSTEMS USING 2,5-DIAMINOTETRALINES | BOEHRINGER INGELHEIM KG (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0402923-A2 | 2,5-Diaminotetralines, process for their preparation and their use as medicine | BOEHRINGER INGELHEIM KG (DE) | 1990-12-19 | — | — | EP | disclosed |