Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.71 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340105 | 0.89 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL7279657 | 0.86 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7273701 | 0.85 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7271411 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL7280371 | 0.80 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL5964701 | 0.74 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2457079 | 0.73 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL7281855 | 0.73 | KAT2B (0.50) | PDE4BPDE4DKAT2BMAPTLMNA | |
| SCHEMBL7272290 | 0.73 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL7338034 | 0.72 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |