Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.76 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279657 | 0.87 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7271411 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP2C19 | |
| SCHEMBL7328426 | 0.85 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL7280371 | 0.81 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL7340105 | 0.78 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL2457079 | 0.76 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL9267553 | 0.75 | MAPT (0.47) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL9132147 | 0.75 | MAPT (0.52) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5249954 | 0.74 | HPGD (0.64) | PDE4BPDE4DMAPTHPGDMEN1 | |
| SCHEMBL10427752 | 0.73 | KMT2A (0.50) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0459505-B1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5536730-A | ANTIINFLAMMATORY, ANTIALLERGIC AND BRONCHODILATIVE ACTIVITY | KYOWA HAKKO KOGYO CO. LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5468756-A | Antiinflammatory, antiallergen | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-21 | — | — | US | disclosed |
| US-5364859-A | Antiinflammatory agents, antiallergens, bronchodilators | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-15 | — | — | US | disclosed |
| EP-0459505-A1 | Imidazonaphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-04 | — | — | EP | disclosed |