Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.55 |
| ▸ | PDE4A | P27815 | 7/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324802 | 0.90 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL7324806 | 0.90 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL7326299 | 0.89 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL7301099 | 0.85 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL30025682 | 0.85 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL7301103 | 0.85 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL7325691 | 0.81 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7325686 | 0.81 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7929068 | 0.81 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL28496638 | 0.81 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |