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SCHEMBL7328452

SCHEMBL7328452

CNC(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CN1C(=O)c2cccc3cccc(c23)C1=O)P(=O)(OCc1ccccc1)OCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 17/20 0.45
▸ MMP9 P14780 5/20 0.44
▸ MMP2 P08253 6/20 0.44
▸ MMP3 P08254 5/20 0.44
▸ REN P00797 1/20 0.43
▸ MMP7 P09237 3/20 0.42
▸ MMP14 P50281 1/20 0.42
▸ MMP8 P22894 3/20 0.41
▸ FCER2 P06734 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7322307 0.91 MMP1 (0.48) MMP1MMP9MMP2MMP3REN
SCHEMBL9348262 0.87 MMP1 (0.51) MMP1MMP9MMP2MMP3REN
SCHEMBL7322384 0.85 MMP1 (0.54) MMP1MMP9MMP2MMP3REN
SCHEMBL9289931 0.84 MMP1 (0.54) MMP1MMP9MMP2MMP3MMP7
SCHEMBL7327878 0.84 MMP1 (0.54) MMP1MMP9MMP2MMP3MMP7
SCHEMBL7320781 0.83 MMP1 (0.50) MMP1MMP9MMP2MMP3MMP7
SCHEMBL7363513 0.81 MMP1 (0.51) MMP1MMP9MMP2MMP3REN
SCHEMBL7320159 0.80 MMP1 (0.53) MMP1MMP9MMP2MMP3MMP7
SCHEMBL7322291 0.78 MMP1 (0.54) MMP1MMP9MMP2MMP3MMP7
SCHEMBL7322283 0.78 MMP1 (0.54) MMP1MMP9MMP2MMP3MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0612324-A1 PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1994-08-31 — — EP disclosed
WO-1993009136-A1 PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1993-05-13 — — WO disclosed