SCHEMBL7328467

SCHEMBL7328467

Brc1cn2cc(-c3ccccc3)nc2c(Br)n1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 5/20 0.71
ADORA2A P29274 4/20 0.57
ALDH1A3 P47895 4/20 0.50
ALDH1A2 O94788 3/20 0.50
NPC1 O15118 5/20 0.49
RAB9A P51151 5/20 0.49
ALDH1A1 P00352 4/20 0.49
KDM4E B2RXH2 4/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
HPGD P15428 3/20 0.49
HSD17B10 Q99714 3/20 0.49
TP53 P04637 2/20 0.49
TSHR P16473 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
TMIGD3 P0DMS9 3/20 0.46
MAPT P10636 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
ADORA3 P0DMS8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7315222 0.80 ADORA1 (0.62) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL973108 0.74 ALDH1A3 (0.70) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31154191 0.71 ALDH1A3 (0.56) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31367425 0.69 ALDH1A3 (0.54) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31367492 0.69 ALDH1A3 (0.54) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL973321 0.69 ALDH1A3 (0.54) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31367558 0.69 ALDH1A3 (0.54) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31367491 0.69 ALDH1A3 (0.57) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL22307609 0.69 ADORA1 (0.57) ADORA1ADORA2AALDH1A3ALDH1A2NPC1
SCHEMBL31367607 0.69 ALDH1A3 (0.63) ADORA1ADORA2AALDH1A3ALDH1A2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119365461-A Non-chelating non-reducing iron death inhibitor and preparation method and application thereof 成都恒昊创新科技有限公司 2025-01-24 CN disclosed
WO-2023246846-A1 NON-CHELATING AND NON-REDUCING FERROPTOSIS INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF 成都恒昊创新科技有限公司 2023-12-28 WO disclosed
US-5028605-A Antispasmodic, bronchodilators, uterine relaxants, cardiac analeptics, neurosedatives L'UNIVERSITE DE MONTPELLIER I (FR) 1991-07-02 US disclosed
EP-0348392-A1 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY Université Montpellier I (FR) 1990-01-03 EP disclosed
WO-1988004298-A1 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1988-06-16 WO disclosed