Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 2/20 | 0.53 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328548 | 1.00 | ITGA4 (0.53) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL10447913 | 1.00 | ITGA4 (0.53) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL7316995 | 0.86 | ITGA4 (0.54) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL23901563 | 0.85 | ITGA4 (0.58) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL23999577 | 0.85 | ITGA4 (0.58) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL10969556 | 0.84 | TACR1 (0.53) | POLBCTSSCTSLCTSBCTSK | |
| SCHEMBL7436482 | 0.84 | ITGA4 (0.53) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL7436535 | 0.84 | ITGA4 (0.53) | ITGA4ITGB7POLBTDP1MAPT | |
| SCHEMBL2140333 | 0.83 | POLB (0.53) | POLBMAPT | |
| SCHEMBL6903056 | 0.83 | POLB (0.52) | POLBTDP1MAPTNPSR1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |